Scientist - Oligonucleotide Biology

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United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. 

Your Role:

The Oligonucleotide Therapeutics group is seeking a highly motivated and collaborative Scientist to support the discovery, characterization, and optimization of oligonucleotide therapeutics across a range of disease areas. This role is intended for an experimental molecular and cellular biologist who combines a strong foundation in RNA biology with hands-on experience in cell-based assay development, mechanistic studies, and translational research. In this role, you will help advance novel oligonucleotide therapeutics from early discovery toward preclinical development by developing robust in vitro assays, generating high-quality biological data, and contributing to the selection of next-generation therapeutic candidates.

You will be responsible for designing, executing, and optimizing cellular and molecular biology workflows to evaluate oligonucleotide activity, including target engagement, mRNA knockdown, protein modulation, and mechanism of action. You will establish quantitative molecular biology workflows, optimize cell-based assay platforms, and apply data-driven insights to support candidate prioritization and translational decision-making. Working closely with chemistry, formulation, and translational research teams, you will help evaluate novel oligonucleotide sequences, chemical modifications, and delivery strategies while contributing to the advancement of our oligonucleotide therapeutic platform.

Responsibilities:

• Design, execute, and optimize in vitro assays to evaluate oligonucleotide (ASO, siRNA, LNA) activity, including target engagement, mRNA knockdown, protein modulation, and splice-switching in disease-relevant cell models.


• Establish, optimize, and validate molecular biology workflows including RT-qPCR, Western blotting, flow cytometry, immunofluorescence microscopy, and other cell-based assays to support therapeutic discovery.


• Develop and characterize cellular models to assess oligonucleotide uptake, intracellular trafficking, pharmacodynamic responses, and mechanism of action.


• Perform dose-response and time-course studies to evaluate oligonucleotide potency, durability, and pharmacological activity.


• Analyze experimental data, identify trends, troubleshoot technical challenges, and recommend next-step experiments to advance lead optimization.


• Collaborate with multidisciplinary teams, including chemistry, formulation, and bioinformatics, to evaluate oligonucleotide sequences, chemical modifications, and delivery strategies.


• Support implementation of laboratory automation and high-throughput workflows to improve assay robustness, reproducibility, and efficiency.


• Maintain accurate experimental records and document procedures, results, and conclusions in accordance with internal standards and good laboratory practices.


• Present scientific findings at project team meetings and contribute to internal reports, scientific presentations, and publications.


• Maintain a safe, organized laboratory environment while adhering to company safety policies and laboratory best practices.

Who You Are:

Minimum Qualifications:

• PhD in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 1+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies

OR

• Master’s degree in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 3+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies

Preferred Qualifications:

• Experience culturing and maintaining mammalian cell lines and developing robust cell-based assays for therapeutic discovery


• Strong experience developing and executing cell-based assays to evaluate target engagement, gene expression, and pharmacodynamic endpoint


• Proficiency in molecular and cellular biology techniques including RT-qPCR, Western blotting, ddPCR, ELISA/MSD immunoassays, flow cytometry, fluorescence microscopy, and mammalian cell culture


• Experience designing, optimizing, and executing medium- to high-throughput cell-based screening assays using multiple mammalian cell lines to evaluate oligonucleotide potency, target engagement, and pharmacodynamic responses


• Familiarity with oligonucleotide chemical modifications, delivery technologies, and mechanism-of-action studies


• Experience with laboratory automation, high-throughput screening, or Design of Experiments (DoE)


• Knowledge of translational biomarkers, pharmacodynamic assays, and target engagement strategies


• Demonstrated ability to independently design experiments, analyze complex datasets, troubleshoot technical challenges, and communicate scientific findings


• Excellent organizational, written, and verbal communication skills


• Ability to work effectively in a collaborative, cross-functional research environment

Pay Range for this position: $95,900 - $143,800

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!