Senior Accountant, Accounting & Finance

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

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  HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

  
  

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  HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

  
  

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  HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

  
  

Colorectal Cancer (CRC)

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  HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

  
  

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview of Role:

We are seeking a highly skilled Senior Accountant to join our growing Finance team. This role is critical in ensuring accurate financial reporting for our global clinical programs and requires strong analytical skills, deep understanding of clinical trial accounting, and the ability to partner effectively with cross functional teams. The ideal candidate thrives in a fast-paced environment, takes ownership, and brings a continuous improvement mindset.

Role and Responsibilities:

• Support the Sr. Manager, Finance Operations in leading the monthly close process, ensuring timely, accurate, and GAAP compliant reporting. Proactively identify opportunities to streamline close activities and improve efficiency across clinical accounting workflows.


• Prepare, own, and continuously refine clinical trial accruals, ensuring accuracy, completeness, and alignment with operational data from Clinical Operations, Study Start-Up Team, and CRO partners.


• Support the accounting and financial tracking for all clinical trial accruals, ensuring data integrity, audit readiness, and compliance with internal policies and external reporting requirements.


• Manage the end‑to‑end site payments process, including invoice review, validation against Clinical Trial Agreements (CTAs), coordination with Clinical Operations, and timely resolution of discrepancies with sites and third‑party vendors.


• Support month‑end and year‑end close activities, including preparation of accruals, reconciliations, and variance analyses related to clinical trial spend and site payments.


• Maintain and monitor SOX controls related to clinical and operational accounting, ensuring all controls are executed on time and function effectively. Proactively identify, document, and escalate any control gaps or deficiencies.


• Assist with audit preparation by gathering needed documents, preparing schedules (PBCs).


• Assist with special projects as they arise.

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Experience, Education and Specialized Knowledge and Skills:

• Bachelor’s degree in finance, business, accounting or related field preferred


• A minimum of 4+ years of experience in accounting


• CPA or progress toward designation preferred


• Experience in the life sciences industry, with prior exposure to clinical study accruals strongly preferred


• Strong understanding of GAAP, internal controls, SOX controls and month-end close procedures required


• Must be proficient in handling large-scale financial data using Excel and financial systems for accurate analysis and reporting


• High level of accuracy and attention to detail


• Strong analytical skills, attention to detail, and ability to work independently.


• Demonstratable experience of working within a fast-paced finance function


• Demonstratable experience of prioritizing workload and managing multiple tight deadlines effectively under pressure in a fast-paced environment


• Excellent communication skills with the ability to forge strong internal and external working relationships, and the confidence to challenge information constructively


• A collaborative, approachable team player with a can‑do attitude

Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at [email protected] to obtain prior written authorization before referring any candidates to Summit.

Summit Therapeutics Inc. is an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment, hiring, training or promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.