Senior Associate Scientist, Oncology Research - In Vivo

Engage in investigative RNAi research evaluating siRNA delivery and efficacy to diverse oncology animal models. Develop and perform in vivo and ex vivo studies using molecular and biochemical techniques to characterize distribution and activity of a variety of siRNAs. Routine tasks would include cancer cell line culture, in vivo efficacy, and PK/PD studies as well as processing harvested tissue for ex vivo analyses. Analyze and interpret data and communicate results to the team. Collaborate with team members to progress drug discovery efforts, contributing to a dynamic, exciting culture that embraces teamwork, innovation, and transparency. BS or MS in Animal/Veterinary Sciences, Cell/Molecular Biology, Biochemistry, or related field. 3-5 years of research experience in industry conducting in vivo pharmacology studies using mouse tumor models is essential. Expertise in mouse handling, dosing, subcutaneous and orthotopic tumor implantation, and tissue harvesting and collection. Experience working with syngeneic and immune-compromised mice required. Direct experience monitoring tumor growth using IVIS or Lago and software analysis required. Proficiency in multiple dosing routes i.e. IP, IV, SC, intratumoral and blood collection (RO or submandibular) required. Experience in tumor cell line tissue culture required. Stereotaxic procedures, intrathecal (IT), and intracerebroventricular (ICV) dosing in mice a plus. Experience in molecular biology techniques including RNA/DNA/protein extraction, qPCR, Western blot, ELISA a plus. Basic understanding of standard cancer therapeutics and immuno-oncology a plus. Experience using Prism, IVIS or Lago software analysis, Excel required. Ability to follow SOPs, execute, analyze, interpret, and troubleshoot experiments. Excellent lab technique and the ability to work independently. Good documentation of all experimental procedures and results in an ELN. Excellent communicator, team-oriented, and able to handle multiple different projects/experiments at once.