Senior Director of Program and Portfolio Management (PPM)

About Tonix*

Tonix is a fully integrated biotechnology company, publicly traded on NASDAQ (ticker: TNXP), with marketed products and a pipeline of development candidates The Company is focused on commercializing, developing, discovering, and licensing therapeutics to treat and prevent human disease. In August 2025, Tonix received FDA approval for Tonmya™ (cyclobenzaprine HCl sublingual tablets), a first-in-class, once-daily, non-opioid treatment for fibromyalgia. Tonmya is the first new fibromyalgia therapy approved in over 15 years, following successful Phase 3 trials demonstrating significant symptom improvement. Commercial launch is expected in the fourth quarter of 2025. Tonix also markets Zembrace® SymTouch® (sumatriptan injection) 3 mg and Tosymra® (sumatriptan nasal spray) 10 mg, both indicated for the treatment of acute migraine with or without aura in adults.

Tonix’s development portfolio includes product candidates in central nervous system (CNS), immunology, immuno-oncology infectious disease and rare disease. The CNS pipeline features both small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions. The immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer. The infectious disease pipeline includes a vaccine in development to prevent smallpox and monkeypox, which also serves as a live virus vaccine platform for other infectious diseases. Finally, the rare disease portfolio includes a product in development for Prader-Willi syndrome, which has both orphan drug designation and rare pediatric disease designation grants from the FDA.

Tonix owns and operates a state-of-the art infectious disease research facility in Frederick, Md.

Please visit www.Tonixpharma.com for specifics on the pipeline.

*All of Tonix’s product candidates are investigational new drugs or biologics and have not been approved for any indication.

Position Overview

Tonix is looking for a full-time Senior Director of Program and Portfolio Management (PPM) to effectively shape and implement PPM strategies decision making for a complex portfolio of drug development programs and execution of decisions. The Senior Director of PPM will be a responsible for implementing portfolio management best practices, drafting strategic and operational plans, mentoring project managers (PM) and operational staff, and supporting effective communications across multiple departments at Tonix. The individual in this position will also be responsible for building out the team of PMs which would report into this role. 

This is a fast-paced, challenging position offering a competitive compensation and benefits package.  This position will report directly to the Company’s Chief Operating Officer that will ideally be based at the Tonix Chatham, NJ office. 

Essential Duties

• Lead and manage cross-functional teams interacting with clinical, nonclinical, regulatory, CMC, discovery, and others to set priorities, work toward goals and monitor progress of programs


• Develop portfolio tools and materials to support portfolio decision-making


• Create, implement, and refine PPM practices to support leadership, PPM staff, and delivery of program goals


• Lead regular portfolio operations committee meetings and portfolio strategy sessions


• Coordinate and manage due diligence teams and decision making on in licensing activities for the portfolio 


• Help to buildout and lead PMs responsible for developing cross-functional program plans, timelines, and budgets in collaboration with functional area leads


• Facilitate effective, science-based business decisions including development of scenarios and strategic impact of decisions


• Ensure all decisions are assessed as to their risks and impacts as well as accountable for communication to team and stakeholders in a transparent and timely manner


• Function as an integrator within the project team and across the Company to ensure alignment


• Develop and coordinate resource and budget planning activities across functions to ensure adequate resources are applied to the programs and decisions are assessed for portfolio impact


• Provide leadership to teams and functional areas to proactively anticipate and identify project issues which pose a challenge to achieving strategic goals; propose and implement plans to resolve such issues, and execute corrective actions


• Effectively execute change management to implement strategies for effecting, controlling, and helping teams adapt to change


• Provide updated project information for the Board as well as for regular budget and portfolio reviews


• Enable high-performing teams by ensuring good team dynamics within the project team


• Follow all established occupational health and safety procedures, good manufacturing practices (GMP’s) and standard operating procedures (SOP’s)


• Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork


• Perform ad-hoc work/special projects as necessary to support Tonix on various business initiatives

Supervisory Responsibilities

• Recruits, interviews, hires, and trains new team members 


• Oversees the daily workflow of the department


• Provides constructive and timely performance evaluations


• If necessary, handles discipline and termination of employees in accordance with company policy


• Contributes to performance and compensation decisions such as: merit raises, bonuses, and promotions

Minimum Qualifications

• Bachelor’s degree and fifteen (15) years of relevant project / program / portfolio management experience within the pharmaceutical / biotechnology industry; or a PhD in a scientific field or a PharmD, DVM or MD degree with ten (10) years of relevant experience preferred


• Scientific background and/or MBA preferred


• Ten (10) years of leading cross-functional program or portfolio management activities within the pharmaceutical industry with a deep understanding of practices and standards of pharmaceutical program and portfolio management preferred


• Experience managing PM professionals in the drug development industry 


• Strong leadership presence with the ability to translate strategy into action


• Excellent analytical skills with an ability to summarize and present complex information in a clear and concise manner to support decision-making


• Ability to create an inclusive environment and lead empowered teams who operate with high standards of alignment, trust, accountability, expertise, transparency, and collaboration


• Outstanding verbal and written communications skills with the ability to effectively interact with and influence all levels within the company


• Ability for minimal travel


• Dedicated team player who is able to withstand the high demands of a fast-paced environment


• Demonstrated ability to perform the essential duties of the position with or without accommodation

Recruitment & Staffing Agencies

Tonix does not accept agency resumes unless contacted directly by internal Tonix Talent Acquisition. Please do not forward resumes to Tonix employees or any other company location; Tonix is not responsible for any fees related to unsolicited resumes.

Compensation & Benefits

Tonix provides a comprehensive compensation and benefits package which includes:

• Medical, Dental & Vision Insurance, Basic and Voluntary Life and AD&D Insurance, Short- and Long-Term Disability Insurance, Flexible Spending Accounts, Health Savings Account, and Employee Assistance Programs


• Pet Insurance


• Retirement Savings 401k with company match and annual discretionary stock options


• Generous Paid Time Off, Sick Time, & Paid Holidays


• Career Development and Training

Tonix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, genetics, or any other characteristic protected by law.  In addition to federal law requirements, Tonix complies with applicable state and local laws governing nondiscrimination in employment.  This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training.  Tonix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, veteran status, or any other characteristic protected by law.