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Senior Director, Preclinical Program Lead

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Job Description - Senior Director, Preclinical Program Lead

BlueRock Therapeutics is at the forefront of cellular therapy, dedicated to developing groundbreaking medicines that significantly improve patients' lives suffering from neurological and ophthalmological disease. We are seeking a highly collaborative and dynamic individual to join our New York City site (in person) as a Preclinical Program Lead, Retinal Cell Therapies and Translational Neuroscience. The role has two primary focus areas in acting as Program Lead for the OpCT-002/003 preclinical program and Translational Neuroscience Coordinator for BlueRock’s preclinical assets. Reporting directly to the CSO, this role will be instrumental in advancing our cell+gene pipeline. This role requires significant industry experience and specific, deep knowledge of retinal cell biology, along with demonstrated clinical development experience.

This is an ideal opportunity for a clinical developer who is passionate about research, or vice versa, eager to bridge the gap between early discovery and patient impact.

This is an exceptional opportunity for a talented scientist to make a tangible impact on a new class of medicines and gain invaluable career experience within the cell therapy field. You'll join a highly motivated, world-class team of scientists and engineers in an exciting and engaging work environment.

Responsibilities

    • 1. Preclinical Program Lead, OpCT-002/003 (Matrixed Management):
    • · Serve as the biology subject matter expert and an intellectual contributor for our preclinical OpCT-002/003 program, which is entirely executed by our external collaborator, Opsis Therapeutics (https://www.bluerocktx.com/bluerock-therapeutics-fujifilm-cellular-dynamics-and-opsis-therapeutics-enter-into-a-strategic-rd-alliance-to-discover-and-develop-cell-therapies-for-eye-diseases/) .
    • · Provide matrixed management and oversight of this collaborative program, ensuring alignment with BlueRock's strategic goals and efficient progression through development stage gates towards an IND.
    • · Cultivate and maintain strong relationships with Opsis Therapeutics investigators and key opinion leaders in the field.

    • 2. Translational Neuroscience Coordinator:
    • · Coordinate translational neuroscience approaches across BlueRock's preclinical assets.
    • · Develop and execute a robust preclinical translational strategy, including the identification and validation of biomarkers and imaging biomarkers to support program advancement.
    • · Interface seamlessly with Program Leads, our in vivo team lead and colleagues from our Development team, including Clinical, Toxicology, and Commercial, to ensure a cohesive and integrated development strategy.
    • · Actively contribute to aligning clinical strategy with a strong focus on patient outcomes and fulfilling a clear commercial need.
    • · Establish, grow, and maintain key relationships with global leaders in retinal cell biology, cell and gene therapy, and translational medicine fields, including BlueRock Advisory Boards.

Requirements

    • PhD in Biomedical Sciences, Retinal Cell Biology, Neuroscience, or a related discipline, or an M.D. · 12+ years of relevant, full-time industry or academic lab experience, with a significant portion gained within the pharmaceutical/biotechnology industry.
    • Demonstrated experience in clinical development, including understanding of regulatory pathways and the translation of preclinical findings into clinical trials.
    • Deep knowledge of retinal cell biology, regenerative medicine, screening assays, and biomarkers.
    • Proven experience in developing preclinical translational strategies, including the identification and implementation of biomarkers and imaging biomarkers.
    • Proven ability to lead by example within a matrixed, dynamic, and high-growth team, championing and advancing novel concepts within cross-functional teams.
    • Experience managing research relationships with external partners
    • An innovative, results-oriented, and solutions-focused mindset with exceptional critical thinking skills.
    • Demonstrated track record in scientific research within the pharmaceutical/biotechnology industry.
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