(Senior) Manager, Statistical Programming

Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation.

Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs.

Description of Role

The (Senior) Manager, Statistical Programming will support statistical programming activities across one or more therapeutic areas, ensuring high‑quality data analysis and compliance with regulatory standards. This role will contribute to the development, implementation, and maintenance of statistical reporting standards and efficient programming processes. The (Senior) Manager will work closely with cross‑functional teams to execute programming deliverables, support clinical development planning, and help enable timely and accurate data outputs for multiple indications at Centessa.

Key Responsibilities

• Support statistical programming activities within a team environment, ensuring alignment with project priorities.


• Collaborate with cross‑functional teams on clinical study planning and execution to ensure accurate and reliable data reporting.


• Ensure the quality and timely delivery of statistical analyses, data outputs, and regulatory submission deliverables.


• Apply strong technical programming expertise and encourage best practices in programming tools, environments, and methodologies.


• Coordinate day‑to‑day resource utilization and contribute to capacity planning in support of departmental objectives.


• Supervise and mentor statistical programming staff, providing training, guidance, and performance support.


• Ensure adherence to CDISC standards (SDTM, ADaM) and compliance with applicable regulatory requirements.


• Oversee and perform the development of tables, listings, and figures (TLFs) for clinical study reports and related deliverables.

Qualifications

• Bachelor’s degree required; advanced degree strongly preferred.


• 8+ years of experience within biotechnology, pharmaceutical, or CRO settings required.


• Prior experience with both early‑phase and late‑phase clinical trials required


• Prior experience working on efficiently working with Adhoc


• Prior experience working efficiently on regulatory submissions, such as NDA and EMA filingsSolid understanding of statistical reporting processes, regulatory expectations, and the software development life cycle.


• Proficiency in SAS programming; familiarity with R or Python is a plus.


• Hands‑on experience working with CDISC standards (SDTM, ADaM) and programming from raw datasets through analysis‑ready outputs.


• Strong written and verbal communication skills.


• Ability to work effectively in a cross‑functional, matrixed environment and contribute proactively to team deliverables and problem‑solving.

Compensation

The annual base salary range for the manager level is $120,000.00 to $157,000.00.

The annual base salary range for the senior manager level is $145,000.00 to $190,000.00.

 Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success.

Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

The (Senior) Manager, Statistical Programming role is a remote role based in the US, with occasional travel.

POSITION: Full-Time, Exempt

EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.