Senior Medical Director, US Medical Affairs - TTR

Overview\n\nThe Senior Medical Director, US Medical Affairs \u2013 TTR is accountable for leading the end-to-end US evidence generation strategy and execution in close partnership with Global Medical Affairs. This role drives the development of high-impact, non-promotional evidence to support clinical understanding, inform treatment decisions, and improve patient outcomes in transthyretin (TTR) amyloidosis.\n\nThis individual will oversee US-based Investigator-Sponsored Studies (IIS/IIT), real-world evidence (RWE) initiatives, and serve as the US medical lead for publications, ensuring strong US input and execution within the global publications framework. The role includes direct management of an Associate Director and leadership across key enterprise evidence initiatives, including VEST and Health Systems evidence generation.\n\nKey Responsibilities\n\nEnd-to-End US Evidence Generation Leadership\n\n\u2022 Own and lead the end-to-end US evidence generation strategy and execution, aligned with global medical and enterprise priorities\n\n\u2022 Identify and prioritize US-specific evidence gaps and translate them into actionable study plans\n\n\u2022 Drive development and execution of RWE, observational studies, registries, and database analyses (e.g., EHR, claims)\n\n\u2022 Ensure seamless execution across the study lifecycle: concept development, protocol design, governance, execution, analysis, and dissemination\n\n\u2022 Deliver high-quality, timely, and impactful evidence to support clinical practice and patient outcomes\n\nHealth Systems Evidence Generation Leadership\n\n\u2022 Serve as the US medical lead for Health Systems evidence generation strategy and execution\n\n\u2022 Develop and advance evidence to demonstrate value in real-world clinical practice, including outcomes, healthcare utilization, and system-level impact\n\n\u2022 Partner cross-functionally (e.g., HEOR, Market Access, Commercial, Global Medical) to align on priorities and maximize evidence impact\n\n\u2022 Ensure integration of health systems evidence into broader US and global evidence strategies\n\nInvestigator-Sponsored Studies (IIS/IIT) Oversight\n\n\u2022 Provide strategic and scientific oversight of the US IIS/IIT portfolio\n\n\u2022 Lead evaluation, prioritization, and governance of IIS proposals aligned with medical strategy\n\n\u2022 Partner with investigators to shape robust, hypothesis-driven research\n\n\u2022 Ensure compliance with internal policies, regulatory requirements, and ethical standards\n\nPublications (US Medical Lead)\n\n\u2022 Serve as the US Medical Affairs lead for publications, ensuring strong US input into global publication strategy\n\n\u2022 Partner with Global Medical Affairs to align on publication priorities, timelines, and execution\n\n\u2022 Lead execution of US-led publications (abstracts, posters, manuscripts) in alignment with global plans\n\n\u2022 Provide medical review to ensure scientific accuracy, relevance, and compliance\n\n\u2022 Collaborate cross-functionally to ensure appropriate integration of clinical, RWE, and HEOR data\n\nVEST Leadership\n\n\u2022 Serve as the primary US Medical lead to the VEST team, representing US medical priorities and ensuring alignment with enterprise evidence strategy\n\n\u2022 Provide strategic input into VEST initiatives and ensure execution of US evidence components\n\n\u2022 Act as a key connector between US Medical and cross-functional stakeholders involved in VEST\n\nPeople Leadership\n\n\u2022 Directly manage and develop one Associate Director\n\n\u2022 Provide clear direction, prioritization, and coaching to ensure high performance and professional growth\n\n\u2022 Foster a culture of accountability, collaboration, and scientific excellence\n\nCross-Functional Leadership\n\n\u2022 Serve as a key medical partner across US and Global Medical Affairs, Clinical Development, HEOR, Market Access, and Commercial teams\n\n\u2022 Translate complex data into clear, actionable insights for internal stakeholders\n\n\u2022 Support field medical teams with evidence strategy and emerging insights\n\n\u2022 Contribute to lifecycle management and differentiation through evidence generation\n\nExternal Engagement\n\n\u2022 Build and maintain relationships with key opinion leaders (KOLs), academic institutions, and research networks\n\n\u2022 Support strategic research collaborations aligned with US evidence priorities\n\n\u2022 Represent the organization at scientific meetings and investigator interactions\n\nQualifications\n\nEducation \u0026 Experience\n\n\u2022 MD, PharmD, or PhD in a relevant scientific or clinical discipline\n\n\u2022 8\u201312+ years of experience in Medical Affairs, Clinical Development, or related functions\n\n\u2022 Demonstrated experience leading evidence generation (RWE, IIS/IIT) and supporting publications\n\n\u2022 Prior people management experience preferred\n\n\u2022 Experience in rare disease, cardiovascular, or related therapeutic areas preferred\n\nSkills \u0026 Capabilities\n\n\u2022 Strong ownership mindset with ability to lead end-to-end strategy and execution\n\n\u2022 Deep understanding of RWE methodologies, study design, and health systems evidence\n\n\u2022 Proven ability to lead cross-functional initiatives in a matrixed, global environment\n\n\u2022 Strong communication and executive presence\n\n\u2022 High integrity and commitment to compliance and scientific excellence\n\nLeadership Expectations\n\n\u2022 Enterprise thinker with strong ownership and accountability\n\n\u2022 Balances strategic vision with disciplined execution\n\n\u2022 Builds and develops talent\n\n\u2022 Trusted scientific leader internally and externally\n\n#LI-JB1 #LI-Hybrid\n\nU.S. Pay Range\n\n$266,800.00 - $361,000.00\n\nThe pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).\n\nAlnylam\u2019s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.\n\nLearn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers\n\nAbout Alnylam\n\nWe are the leader in RNAi therapeutics \u2013 a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what\u2019s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We\u0027re proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.\n\nAt Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.\n