Senior MES Engineer Life Sciences / Manufacturing Execution Systems

Senior MES Engineer – Life Sciences | Raleigh, NC | Hybrid

Location: Raleigh, NC (Hybrid) | 25% Travel Required
Salary: $145K–$180K Base + 20–35% Bonus
Schedule: Full-Time, Hybrid

About Us:
We are a 100% employee-owned, ENR Top 500 engineering firm with 40+ years of experience delivering complex automation, MES, and system integration solutions. With offices across the U.S. and over 500 experts on staff, we provide life sciences and industrial clients with innovative, compliant, and efficient manufacturing solutions.

Role Overview:
We are seeking a Senior MES Engineer to lead the design, implementation, and commissioning of MES (Manufacturing Execution System) solutions in the Life Sciences industry. This is a leadership role for a technically skilled, hands-on professional capable of architecting MES systems, guiding teams, and driving client success. You will also have the opportunity to develop and lead our Raleigh MES office.

Key Responsibilities:

• Lead MES solution projects from concept to commissioning, ensuring compliance with cGMP and 21 CFR Part 11.
• Act as Solution Architect for MES integrations across ERP, LIMS, control systems (PLC/DCS), historians, and reporting platforms.
• Deploy MES platforms such as Werum PAS-X, Sepasoft, or POMS for Life Sciences manufacturing.
• Develop project plans, budgets, and schedules, and oversee project profitability up to $1M+.
• Mentor and lead engineering teams, guiding junior engineers and technicians.
• Collaborate directly with clients to gather requirements, recommend optimal system designs, and deliver efficient, compliant solutions.
• Support business development efforts, including trade shows, associations, and client relationship growth.

Qualifications:

• Bachelor of Science in Engineering, Computer Science, or Applied Sciences required.
• 10+ years MES experience, with at least 4 years in Life Sciences.
• Proven experience with MES deployment, integration, and full lifecycle management (concept, design, implementation, testing, commissioning).
• Deep knowledge of GAMP5, S88, and S95 standards for EBR and process integration.
• Familiarity with ERP, LIMS, DeltaV, SAP, PI, Maximo, and relational databases (SQL, Oracle).
• Strong understanding of manufacturing processes, warehouse/inventory management in GMP environments.
• Ability to travel up to 25%.
• Excellent leadership, problem-solving, and communication skills.

Why Join Us:

• Be part of a 100% employee-owned ESOP company with career growth potential.
• Lead innovative Life Sciences MES projects with autonomy and impact.
• Hybrid work model with access to the Raleigh office and client sites.
• Competitive base salary plus discretionary bonus (20–35%).
• Join a top-rated system integrator and ENR Top 500 firm with a long-standing industry reputation.