Senior Modeling and Simulation Scientist (Billerica MA)

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.  

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. 

Your Role:

New Biological Entities Drug Metabolism and Pharmacokinetics Modeling and Simulation (NBE DMPK M&S) Expert is a scientific, strategic, and operational role in Research and Development (R&D).  Our company is committed to bringing transformational medicines to patients, and you will collaborate in a matrixed environment with other passionate functional experts to deliver novel biotherapeutics. 

You will be responsible for M&S project support from concept to late discovery/early development. You will ensure project teams take data-driven decisions by applying models to inform drug design, drive optimal pre-clinical in vivo study design, consult on best in vitro study design, assess feasibility of different routes of administration, define required formulation concentrations, and thereby increase the probability of success of projects early on. The molecules you will design are multi-specific biologics (including NBEs and ADCs) with non-linear PK/PD relations requiring early quantitative assessment and creative approaches for optimal multi-variate molecular design, and translation of PK and efficacy for human dose predictions. You will ensure that M&S strategies are in line with project team needs and expectations, clearly communicating risks and data gaps, as well as mitigation options. You will ensure results are delivered according to agreed timelines, balancing the resources required and high quality, impactful deliverables.

We are looking for an individual with a proven track record of applying modelling and simulation approaches to biological problems and ideally experience in quantitative pharmacology & pharmacokinetics.

The NBE DMPK M&S expert may also be a member of the Discovery Project Team, depending on the phase of the project. As scientific matter expert, you will also contribute to and may lead scientific initiatives designed to improve the M&S capabilities within our drug discovery organization.

Who You Are

Minimum Qualifications:

• Education in either Systems Biology, Pharmacokinetics, Pharmaceutical/ Biotechnological Sciences, Biomedical/Chemical Engineering, Applied Mathematics, or a related discipline.


• Ph.D./Post-Doc preferably with experience in pharmaceutical/biotechnological industry 

Preferred Qualifications:

• Comprehensive understanding of the concepts of pharmacokinetics and pharmacodynamics during drug discovery & development


• Strong hands-on experience with modeling software (such as: MatLab SimBiology, R/RxODE, Open Systems Pharmacology Phoenix/WinNonlin, NONMEM, Monolix etc).


• Experience with the application of mPBPK and QSP models.


• Experience in Python, C/C++ and/or other programming languages would be advantageous.


• Good understanding of related disciplines (pharmacology, toxicology, nonclinical safety, drug design, bioanalytics, etc.) is desirable.


• Fluent spoken and written English, German or Italian is a plus.

Location: On-site Billerica MA

Pay Range for this position: $142,700 - $214,100

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!