Senior Principal Research Scientist, Analytical Chemistry

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Analytical Research & Development team is seeking a talented, highly motivated candidate with experience in the characterization of peptide and oligonucleotide biomolecules.  The successful candidate will be responsible for leading the design, development, and implementation of analytical methods for the characterization of peptides/oligonucleotides using advanced analytical techniques, with an emphasis on high order characterization.  We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates. The ideal candidate will have significant CMC expertise in analytical development for biomolecule therapeutics. The candidate will be responsible for assisting with the development and execution of analytical methods to support CMC and will participate in phase-appropriate characterization of material and products at all stages of the development process, as well as monitoring completion of tasks and projects.

Responsibilities:

• Lead development and implementation of advanced analytical characterization methods to support complex peptide and oligonucleotide development programs. 
• Utilize cutting-edge structure elucidation techniques (e.g., high-resolution, tandem mass spectrometry) to characterize a wide range of modalities across AbbVie’s pipeline, including oligonucleotide, peptide, and small molecule APIs, starting materials, intermediates, and impurities.
• Lead cross-functional teams and collaborate with multi-disciplinary experts to develop strategies to enable the structure elucidation aspects of a project to advance programs through the development pipeline.
• Advance scientific expertise beyond ARD organization. Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor and train colleagues and assesses current and emerging business challenges enabling functional goal achievement.
• Ensure quality and effectiveness of key results of major project plans through sound design, early risk assessments, and implementation of fallback strategies.
• Source and identify emerging scientific trends in the field of molecular characterization of therapeutics from internal and external sources and assess relevance. Integrate trends into functional short-term objectives. Advance cross discipline technology and direction within area of discipline.
• Apply imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas across disciplines.
• Make significant contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.
• Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances and respond with appropriate new strategies.

• PhD (with 10+ years’ experience) in scientific discipline (e.g., Analytical Chemistry, Biochemistry, Chemical Biology or related field) with previous laboratory experience.
• Deep understanding of peptide and/or oligonucleotide characterization, including higher order structure, chiral identification, and comparability assessments by mass spectrometry and other biophysical techniques (e.g. optical spectroscopy, structure, and binding).  Experience in biomolecule analysis and interpretation by NMR spectroscopy a plus.
• Practical experience and strong knowledge of LC separations (e.g., IP-RP LC, SEC), capillary electrophoresis, and other separation techniques as applied to peptide/oligonucleotide analysis.
• Must possess demonstrated experience in peptide/oligonucleotide chemistry and biochemistry, particularly in the high order characterization activities  related to drug development process and formulation characterization.
• Experiences with the project leadership in the development of peptides and traditional small molecule modalities.
• Proven ability to innovate with a history of new or improved product release.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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