Senior Scientist I, Cell-free Protein Synthesis

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role: 

Generate is seeking a highly creative and technologically curious Senior Scientist I in Cell-free Protein Synthesis to be part of the CFPS group in our prototyping lab. We believe innovations at the intersection of machine learning, computational protein design, and HTP experimentation will transform the ways that we bring new therapies to patients.  

The Senior Scientist will contribute to efforts to expand our intrinsically scalable CFPS platform using synthetic biology, ML-guided optimization and strain engineering, with the aim of increasing throughput, and dramatically shortening design-build-test-learn cycles of our therapeutic candidates. They will work to 1) further integrate CFPS technology into our HTP and Cryo-EM workflows combining synthetic biology, structural biology, automation, and machine learning, 2) optimize and expand our CFPS workflows across modalities, and 3) work closely with our production scientists to design and implement productionized workflows.

The successful candidate has a proven track record of cross-disciplinary quantitative research, combining deep understanding of synthetic biology and high-throughput experimentation. Close collaboration with members from Generate’s Protein Science, Cryo-EM, Computational, and Machine Learning teams will be crucial to produce game-changing novel CFPS workflows. This is an opportunity to perform highly innovative technology development, while being a part of the collaborative and premier scientific environment in a well-funded biotech startup.

Here's how you will contribute:

• Expand Generate’s efforts to integrate CFPS into our HTP screening and Cryo-EM workflows.


• Lead part of the team efforts to optimize CFPS workflows using both experimental tools (strain engineering, synthetic biology, automation, Cryo-EM) and theory (computational analysis, statistics, and ML-guided optimization).


• Work with production and analytics teams in the Protein Sciences department to optimize scaled-up workflows and implement characterization of CFPS-produced material.


• Generate bold, creative, unconventional ideas, and be a point person for intellectual property and patent writing.


• Strategic experiment planning, data interpretation, summarization, and presentation with minimum supervision are required


• Involvement in accelerating the discovery, engineering and characterization of novel biologics in the pipeline programs


• Mentor and train scientists throughout the company.

The Ideal Candidate will have:

• BSc/MSc with 10+ years or PhD+4 years of experience in a relevant science/engineering field (biophysics, biochemistry, physical chemistry, biological engineering, quantitative/synthetic biology, or related discipline).


• Demonstrated expertise in implementation, analysis, and optimization of Cell-Free Protein Synthesis systems.


• Demonstrated experience in laboratory automation and high-throughput experimental design.


• Deep subject matter expertise and experience with Cryo-EM is a plus


• Experience with data analysis in Python, Matlab, R or equivalent is a plus


• Highly motivated, proactive and enthusiastic team player demonstrating flexibility and a sense of urgency

#LI-HM1

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.