Senior Scientist / Principal Scientist, Bioprocess Sciences

Title: Senior Scientist / Principal Scientist, Bioprocess Sciences

Location: San Diego

Job Type: Full-Time

About Us: A stealth-mode biotech focused on developing best-in-class delivery for in vivo gene editing.

Job Summary: We are seeking a highly motivated and experienced scientific expert to join our team as a Senior Scientist or Principal Scientist of Bioprocess Sciences. This role will provide technical expertise for bacterial protein production programs supporting research and development. The successful candidate will be part of a dynamic team of scientists responsible for process development, scale-up strategy and external manufacturing oversight. Title and compensation will be commensurate with experience.

Key Responsibilities:

• Provide technical expertise for bacterial strain engineering, fermentation, protein expression, purification, and protein characterization activities.


• Develop, optimize, and scale bacterial culture and purification processes for internal and external manufacturing.


• Manage and oversee activities at contract development and manufacturing organizations (CDMOs), including tech transfer, process troubleshooting, timelines, and deliverables.


• Partner cross-functionally with research, analytical, quality, and leadership teams to achieve project milestones.


• Establish and maintain robust documentation, protocols, and data packages to support internal decision-making and external partners.


• Prepare and present technical reports, development strategies, and risk assessments to internal stakeholders.


• Stay current with advancements in bioprocessing technologies, manufacturing trends, and regulatory expectations.
  
  

Qualifications:

• D. degree in Chemistry, Biology, Biochemistry, Biomedical Engineering, Chemical Engineering, or a related field.


• 6+ years of progressive experience in bacterial protein expression, purification, and bioprocess development.


• Demonstrated experience leading projects and mentoring or managing scientists.


• Hands-on expertise with affinity-based protein purification (e.g., FPLC), bacterial expression systems, and routine molecular biology assays.


• Strong working knowledge of SDS-PAGE, Western blotting, ELISA, and other biochemical and biophysical assays.


• Experience interpreting QC assays (fluorometric, chromogenic, etc.) and assessing data quality and process performance.


• Routine use of electronic laboratory notebooks (e.g., Benchling) with a strong commitment to data integrity.


• Excellent analytical, communication, and organizational skills with the ability to manage multiple priorities.


• Ability to work independently in a fast-paced, evolving environment.
  
  

Preferred Qualifications:

• Direct experience managing or collaborating with CDMOs for process development or manufacturing.


• Experience with bioreactor operations, scale-up, and tech transfer.


• Protein characterization experience using HPLC/UPLC and/or LC-MS.


• Familiarity with regulatory expectations related to bioprocessing and manufacturing.


• Background in protein engineering or recombinant protein production.
  
  

Benefits:

• Competitive salary, equity, and comprehensive benefits package.


• Opportunities for professional growth and leadership development.


• Fast-paced, collaborative, and innovative work environment.
  
  

How to Apply: Interested candidates should submit their resume and a cover letter detailing relevant experience. To be considered for the role, applicants must be:

• Eligible to work in the United States for any employer without sponsorship.


• Able to work onsite in the lab located in San Diego.


• A direct candidate and not from a third party, i.e., staffing agency.