Senior Scientist, Process Chemistry

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California.

We are seeking a highly motivated process development and chemistry senior scientist. This senior scientist designs and executes multi-step experimental studies, utilizing analytical tools to ensure safe and scalable processes. They collaborate cross-functionally, author technical reports, and facilitate the transfer of technology for GMP manufacturing.

• Design, planning, and execution of multi-step experimental studies to provide safe, efficient, robust and scalable processes.
• Independently use PAT and analytical tools and interpret data to gain reaction understanding.
• Share literature and available resources to support relevant precedent for process research.
• Perform experiments and interpret data (calorimetry, TGA, DSC) to safely scale reactions.
• Author development reports and technical packages, and author/review relevant sections in health authority filings (including INDs, NDAs, annual reports, and any other regulatory interactions) and patents.
• Prepare presentation materials and clearly communicate research results to manager, and at internal/external meetings.
• Working cross-functionally with Analytical and Formulations Development colleagues.

Tech transfer to CMO and scale-up of chemistry, including supporting GMP manufacture.

• PhD in organic chemistry with at least 3 years for Senior Scientist and with 0-2 years’ experience for a scientist of relevant hands-on pharmaceutical/biotech industry experience in the field of new drug development.
• Proven track record for solving process chemistry problems, including identification, optimization, and characterization of robust and scalable synthetic routes.
• Firm understanding of mechanistic organic chemistry.
• Working understanding of analytical tools used in process development (DSC, TGA, DVS, HPLC, NMR, KF, PLM, XRPD).
• Able to work as part of a team with strong interpersonal skills. Excellent oral and written communication skills. Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.
• Demonstrated passion, curiosity, and enthusiasm in pursuing ideas and solutions despite challenges.
• Demonstrated initiative, ownership, problem identification, problem solving, and strategic thinking.
• Experience writing research reports and detailed reaction procedures.
• Demonstrated ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team.
• Consistent demonstrated high performance, above and beyond the minimum expectations and needs.
• Scientific excellence is demonstrated by publications, presentations, and leadership/engagement in the scientific/professional community.
• Awareness and understanding of ICH, GMP, and regulatory guidance that are important to consider in new drug development.
• Excellent oral and written communication skills. Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.

Excellent oral and written communication skills. Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.

The anticipated salary range for candidates is between $175,000-$200,000 in South San Francisco.  The final rate offered to a successful candidate will be dependent on several factors that may include but are not limited to the title, type and length of experience within the job, type and length of experience within the industry, education, etc. 

ORIC Pharmaceuticals, Inc. is an equal opportunity employer. ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristic.