Senior Staff Scientist Biophysics, Yale/NIDA Neuroproteomics Center

Working at Yale means contributing to a better tomorrow. Whether you are a current resident of our New Haven-based community, eligible for opportunities through the New Haven Hiring Initiative, or a newcomer, interested in exploring all that Yale has to offer, your talents and contributions are welcome. Discover your opportunities at Yale!

Overview

The Yale/NIDA Neuroproteomics Center at the Yale School of Medicine seeks an accomplished biophysical scientist for a part-time (10% effort), casual appointment within the Discovery Proteomics Core (DPC). The successful candidate will provide senior-level scientific leadership and oversight of the Biophysics Section, ensuring rigorous quantitative and mechanistic characterization of protein–protein and protein–ligand interactions that extend discovery proteomics into functional domains relevant to addiction neuroscience.
This position plays a critical role in maintaining the Center’s nationally recognized strength in integrated proteomic and biophysical analyses that support NIH-funded research.

Principal Responsibilities
1. Scientific Leadership and Oversight
Provide scientific direction for biophysical analyses within the Discovery Proteomics Core, ensuring appropriate technology selection and rigorous experimental design.
2. Experimental Consultation and Project Development
Collaborate with investigators to design and interpret complex biophysical studies, including analyses of protein structure, oligomerization, binding affinity, thermodynamics, and kinetic rate constants).
3. Technology Oversight and Method Development
Provide high-level oversight and consultation for methodologies including SEC/MALLS, DLS, AFFF, ITC, circular dichroism (CD), surface plasmon resonance (SPR), and nanoparticle tracking analysis (NTA). Contribute to continued development and optimization of extracellular vesicle isolation and
characterization workflows.
4. Data Interpretation and Quality Assurance
Ensure conservative, quantitative interpretation of complex datasets and uphold best practices in analytical rigor and reproducibility.
5. Training and Mentorship
Provide training, consultation, and scientific mentorship to Center investigators utilizing biophysical technologies.
6. Grant and Manuscript Participation
Contribute to Center NIH grant progress reports. Participate in manuscript preparation and scientific dissemination.
7. Research-in-Progress Outreach
Deliver annual Research-in-Progress presentations to Center investigators and staff to introduce, update, and reinforce awareness

Required Skills and Abilities

PhD in Biophysics, Biochemistry, Analytical Chemistry, or a related field and a minimum of 10 years of relevant postdoctoral or above experience in advanced biophysical methodologies.

Extensive experience working within an academic or institutional core laboratory environment is required, including demonstrated leadership in collaborative, fee-for-service or shared-instrumentation settings supporting multiple investigators.

Documented experience contributing to NIH Research Performance Progress Reports (RPPRs) and competing grant renewals involving biophysical or core facility components is required.

Preferred Skills and Abilities

Principal Responsibilities

1. User Training: Refine training methodologies and train and mentor users of the research core, providing guidance and expertise.
2. Experiment Support: Collaborate closely with researchers and lead complex projects requiring customized solutions within the research core.
3. Facility/Instrument Support: Lead and manage research projects within the research core.
4. Technique Development: Contribute to the development of research strategies within the research core and evaluate and implement cutting-edge technologies and methodologies.
5. Data Analysis/Interpretation: Analyze and interpret complex scientific data, providing critical insights and recommendations.
6. Equipment Procurement: Assist in the evaluation, acquisition, and maintenance of research core equipment.
7. Professional Development: Stay updated with emerging research trends and technologies. Participate and present in professional development activities and scientific conferences, representing the research core at conferences and events.
8. Scientific Participation: Collaborate with users on manuscript preparation and grant proposals, as applicable.
9, Staff Training and Mentoring: Mentor and support junior staff members in their professional growth.
10. Leadership: Collaborate with senior core leadership on research core-related initiatives.
11. Finance and Admin: Support the Core Director with development and implementation of strategic plans and budgets for the research core.
12. Vendor Relations: Oversees strategic vendor partnerships, manages negotiations, and evaluates vendor performance for the research core.
13. Education and Outreach: Develop education and outreach activities within the core, including tours, events, etc..

Required Education and Experience

Master's Degree in a related discipline and five years of related experience or an equivalent combination of skills, education, and experience.

Job Posting Date

06/09/2026

Job Category

Professional

Bargaining Unit

NON

Compensation Grade

Administration & Operations

Compensation Grade Profile

Manager; Program Leader (26)

Salary Range

$92,000.00 - $146,750.00

Time Type

Part time

Duration Type

Temporary / Casual (Fixed Term)

Work Model

On-site

Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.

Health Requirements

Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.

Posting Disclaimer

Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job-related duties through  their hiring department.

The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.

Inquiries concerning Yale's Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).

Note

Yale University is a tobacco-free campus.