Sr. Director, Clinical Scientist

Sr. Director, Clinical Scientist

About Climb:

Climb Bio is a clinical-stage biotechnology company developing therapeutics for patients with immune-mediated diseases. Our product candidates include budoprutug, an anti-CD19 monoclonal antibody that presents us with an exciting opportunity given its broad potential applicability across a number of B-cell mediated diseases, including systemic lupus erythematosus, immune thrombocytopenia, and membranous nephropathy and CLYM116, an anti-APRIL monoclonal antibody in preclinical development for IgA nephropathy.

At Climb Bio, our team has a knack for seeing what no one else sees—and a drive to achieve results no one expects. We believe that our combined strength conquers any summit, and our core values – Build Trust, Decide & Commit, Accelerate Impact, and Mark the Moment – guide how we work, collaborate and innovate.  They reflect our commitment to patients, each other, and the pursuit of transformative science. We are seeking an experienced Sr. Director, Clinical Scientist. Reporting to the Chief Medical Officer, this individual will act as a senior scientific leader responsible for the design, execution, and interpretation of clinical studies in support of Climb Bio’s development programs. This is a hands on role that will partner closely with the Medical team, Clinical Operations, and Regulatory.

Key Responsibilities:

Clinical Study Design & Scientific Execution

• Lead or co-lead the design and authoring of clinical protocols, amendments, and associated scientific documents.


• Define study objectives, endpoints, dose rationale, eligibility criteria, and biomarker strategies in collaboration with Medical Directors.


• Ensure studies are scientifically sound and aligned with the target product profile.

Data Review & Interpretation

• Actively participate in study data review, including safety, PK/PD, and biomarker data.


• Partner with key business stakeholders to shape analyses and interpret outputs.


• Contribute to dose escalation and study design discussions and internal data review meetings.

Cross-Functional Collaboration

• Work in close partnership with Medical Directors to support study execution and clinical decision making.


• Collaborate with Clinical Operations to balance scientific rigor with operational feasibility.


• Partner with key business stakeholders to ensure continuity across development stages.

Regulatory & External Support

• Contribute to regulatory documents and interactions, including briefing materials and responses.


• Support investigator engagement, KOL discussions, and advisory boards as a scientific representative.

Leadership & Team Contribution

• Contribute to development of best practices, templates, and standards for clinical science deliverables.


• Serve as a trusted scientific advisor to the CMO and development team.

Qualifications:

• MD, PhD, PharmD, or equivalent advanced scientific degree.


• 8+ years of experience in clinical development in biotech or pharma.


• Hands-on experience supporting and designing Phase 1 and Phase 2 clinical development.


• Strong protocol authoring and data interpretation experience.


• Experience contributing to regulatory submissions and interactions.


• Strong clinical and translational acumen


• Facility with manipulating complex, multidimensional datasets


• Excellent communication skills (written and oral)


• Comfortable working in a collaborative, matrixed environment

This is a hybrid position that can be either remote or based out of our Wellesley, MA office. Base salary offered may vary depending on the individual’s skills, experience, and competitive market value. Additional total rewards include discretionary annual bonus, comprehensive benefits to include Medical, Dental and Vision, Life & Disability, 401k company match, generous paid time off, and equity.

Climb is a publicly traded company. For more information, please visit climbbio.com.

Climb is an Equal Opportunity Employer and we do not discriminate against any employee or applicant for employment because of race, color, sex, age, place of origin, religion, family status, sexual orientation, gender identity, status as a veteran, and disability or any other federal, state, provincial or local protected ground.