Sr. Director of Enterprise Program Management Office

The Sr. Director of Enterprise Program Management Office (ePMO) plays a highly collaborative and internally focused leadership role responsible for driving alignment, coordination, and execution across the organization. This position serves as a central connector across functions including Operations, Quality, Supply Chain, Manufacturing, Technical Operations, Engineering, R&D, Commercial, and Corporate functions to ensure enterprise priorities are effectively integrated and executed.

This role requires a broad understanding of how a small molecule pharmaceutical manufacturing company operates end-to-end, along with the ability to navigate complex cross-functional interdependencies, competing priorities, and organizational change. The Sr. Director will partner closely with leaders and teams across the business to create visibility, improve execution, and drive operational effectiveness in support of Phlow’s strategic goals.

The ideal candidate brings a diverse range of experiences across multiple functions within a small molecule manufacturing environment and is comfortable working both strategically and operationally in a fast-paced, evolving organization.

• Lead and coordinate enterprise-wide programs, projects, and strategic initiatives that require collaboration across multiple departments and functions.
• Develop and maintain consistent project management methodologies, tools, templates, and systems that support organizational alignment, operational agility, and business process standardization.
• Partner closely with leaders and teams across the organization to ensure initiatives remain aligned with company strategy, operational priorities, resource capacity, compliance requirements, and business objectives.
• Serve as a key internal partner and facilitator, helping teams navigate cross-functional dependencies, resolve barriers, improve communication, and maintain execution momentum.
• Build and strengthen the ePMO as a collaborative internal function and Community of Practice that supports organizational effectiveness, continuous improvement, and a culture of accountability and execution excellence.
• Support organizational decision-making by providing executive leadership with clear program visibility, dashboards, reporting, risk assessments, and progress updates.
• Provide guidance, coaching, and mentorship to project managers and cross-functional teams to strengthen project management capabilities across the organization.
• Act as a trusted internal consultant and advisor to project sponsors, department leaders, and governance committees on project execution, prioritization, and organizational coordination.
• Collaborate with executive leadership on strategic planning, enterprise prioritization, and organizational initiatives that support business growth and operational maturity.
• Oversee operational and budgetary management of the ePMO function.
• Perform other duties as assigned.

What it Takes:

• 10+ years of experience in project management, program management, operations, technical operations, manufacturing, or related leadership roles within pharmaceutical, biotechnology, CDMO, or small molecule manufacturing environments.
• Broad cross-functional experience across multiple areas of a small molecule pharmaceutical manufacturing organization strongly preferred.
• Demonstrated ability to work effectively across departments and influence without direct authority in a highly collaborative environment.
• Strong understanding of pharmaceutical manufacturing operations, organizational interdependencies, and regulated environments.
• Proven ability to manage complex enterprise initiatives involving multiple stakeholders, priorities, and timelines.
• Excellent communication, facilitation, organizational, and relationship-building skills.
• Bachelor’s degree in a related field required.
• PMP certification preferred. 

Physical Requirements:

• Constantly required to see to utilize computer screens and monitors to perform job duties including reading & writing, as well as when presenting information and communicating with others. 
• Frequently required to talk or hear to communicate with employees, candidates, vendors, and others, including presenting information in front of groups. 
• Frequently required to sit, and occasionally required to stand or walk to move around primarily in an office environment.