Sr. Medical Director

About TRIANA Biomedicines 

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate. 

Position Overview:

We are seeking a Senior/Executive Medical Director to lead early-phase oncology clinical development. This role serves as the primary medical lead for one or more investigational compounds from first-in-human through proof of concept, driving clinical strategy, ensuring patient safety, and advancing programs toward key milestones.

You will work cross-functionally with translational science, biomarkers, regulatory, and portfolio teams to define and execute development plans. The ideal candidate is a physician-scientist with deep oncology expertise, hands-on early-phase trial experience (including CRO oversight), and a strong commitment to delivering innovative therapies to patients. Regulatory and global experience are a plus.

Key Responsibilities:

Clinical Strategy

• Serve as the Medical Lead for early-phase oncology      programs (FIH through proof of concept). 
• Develop Clinical Development Plans, including      indication strategy, study design, and decision criteria. 
• Define dose-escalation approaches, expansion cohorts,      and patient selection in partnership with translational and biomarker      teams. 
• Drive data-informed decisions through safety reviews,      data analyses, and portfolio discussions. 

Study Design & Execution

• Author and oversee key clinical documents (protocols,      IBs, ICFs, CSRs). 
• Provide medical oversight for trial execution,      including safety monitoring and investigator engagement. 
• Lead medical monitoring activities (AE review, signal      detection, dose management). 
• Participate in or chair SRCs, DMCs/IDMCs, and      internal governance meetings. 
• Partner with biostatistics on endpoints and analysis      plans aligned with regulatory expectations. 

Regulatory & Scientific Engagement

• Contribute to regulatory submissions (INDs,      amendments, briefing documents, responses). 
• Support regulatory interactions as a medical expert      (FDA, EMA, global agencies). 
• Build relationships with KOLs, academic institutions,      and patient advocacy groups. 
• Lead publications and present data internally, at      conferences, and to external stakeholders. 

Cross-Functional Leadership

• Serve as a core Program Team member, providing      medical leadership across functions. 
• Mentor junior clinical staff and contribute to team      development. 
• Support business development activities, including      scientific due diligence and partnerships. 

Qualifications:

Required

• MD, MD/PhD, or DO with board      certification/eligibility in Oncology, Hematology/Oncology, or related      field. 
• 10+ years of industry experience, including 5+ years      in biotech drug development. 
• Proven leadership in Phase I/II oncology trials,      including FIH studies. 
• Strong expertise in oncology biology, biomarkers, and      precision medicine. 
• Experience with regulatory submissions and health      authority interactions. 
• Excellent communication skills with the ability to      translate complex data clearly. 

Preferred

• Experience with accelerated regulatory pathways      (e.g., Breakthrough Therapy, Fast Track, RMAT). 
• Global/ex-US clinical development experience.

We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.

Base Salary: $300-$325k

Our Culture

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.

Our Values

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission. 

Thank you for your interest in TRIANA!