SR Scientist, Antibody Therapeutics Lead

Description

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development, and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in several ways to foster a healthy working environment, meaningful work, mobility, networking, and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

The Senior Scientist contributes to the optimization of therapeutic antibodies in their transition from antibody lead to drug candidate ready for entry into Development by planing and executing the research needed to deliver optimized therapeutic antibody candidates that best fit the target product profile.  This work includes production and characterization of monoclonal antibodies against therapeutic targets for new therapeutic concepts. The position works closely with other teams within New Biological Entities and other functions within the Research and Development organizations to achieve project deliverables. In addition, the Senior Scientist  brings new technologies for the optimization, production and characterization of antibodies to the attention of the team while supporting activities with external collaborators and upholding and reinforcing governance and processes in the context of the projects.

Duties & Responsibilities

Requirements

Eligibility Requirements:

• Must be legally authorized to work in the United States without restriction.


• Must be willing to take a drug test and post-offer physical (if required).


• Must be 18 years of age or older.

Desired Skills, Experience and Abilities

• Design, execute, and clearly communicate analytical characterization of biotherapeutics, including monoclonal antibodies and other protein-based modalities as part of a therapeutic drug research and development pipeline.


• Specific expertise in one or more of the following: intact mass analysis, peptide mapping, and post-translational modifications (PTM) analysis.


• Lead and execute characterization activities, with an emphasis on intact-mass LC-MS technique to elucidate critical quality attributes such as charge variants, size variants, and post-translational modifications of biotherapeutics.


• Provide analytical support for cross-functional teams, including formulation development, upstream/downstream process development, and manufacturing to investigate and solve biotherapeutic development challenges.


• Preparing and analyzing biotherapeutic materials, maintaining and calibrating mass spectrometry instruments, and interpreting complex data sets.


• Independently conduct sample preparation and LC-MS analyses in compliance with SOPs, and document experimental procedures and results in electronic laboratory notebook (ELN).


• Help automate data collection, reporting, and visualization using tools such as Excel or basic scripting.  Experience with scientific programming in Python or R is a plus. 


• Proficiency in operating mass spectrometers, data analysis software, and sample preparation, strong analytical and problem-solving skills, and the ability to work independently while contributing effectively to a team.  Provide subject matter expertise and communicate results at internal meetings.


• Labeling approaches that include amide hydrogen deuterium exchange (HDX).


• 3 to 5 years of hands-on mass spectrometry instrument operation.