Sr. Scientist I /II - Pharmacology

Key responsibilities

• Execute preclinical in vivo studies, including dosing, tumor implantation, monitoring, and tissue and blood collection, following standard operating procedures.
• Develop and apply in vivo oncology models to assess antitumor activity, biomarkers, and pharmacokinetic and pharmacodynamic relationships.
• Design, optimize, troubleshoot, and analyze multicolor flow cytometry panels to characterize tumor and peripheral immune responses.
• Perform ex vivo and in vitro workflows, including cell culture, tumor cell preparation, and tissue processing into single-cell suspensions.
• Generate and interpret high-quality datasets using flow cytometry analysis software and GraphPad Prism for visualization and summaries.
• Maintain accurate experimental documentation in an electronic laboratory notebook and contribute to study reports and presentations.
• Collaborate across functions to communicate findings clearly, support study planning, and advance oncology discovery priorities.

Essential requirements

• Bachelor’s or Master’s degree in Immunology, Biology, or a related scientific field, with relevant laboratory experience.
• Hands-on experience with mouse in vivo studies, including dosing, tumor implantation, monitoring, and tissue collection.
• Experience working with oncology in vivo models, including xenograft or syngeneic systems.
• Strong multicolor flow cytometry expertise, including panel design, optimization, troubleshooting, and data analysis.
• Experience with flow cytometry analysis software such as FlowJo.
• Demonstrated ability to execute experiments independently while producing high-quality, reproducible data.
• Strong data interpretation skills and the ability to present results clearly in a multidisciplinary setting.
• Strong attention to detail, organization, and a collaborative, proactive working style.

Desirable requirements

• Experience establishing cell line-derived xenograft, patient-derived xenograft, or syngeneic tumor models for oncology studies.
• Experience with immune profiling of tumors and secondary lymphoid organs using multicolor flow cytometry.