Sr. Staff Scientist, Advanced Technologies

Based in Fremont, California, Personalis is a genome-oriented diagnostics company pioneering new paradigms in cancer management. We transform patient care through genomic characterization of tumors and ultrasensitive detection of disease recurrence or progression.  To achieve this, we leverage whole-genome, exome, and bespoke targeted sequencing with proprietary algorithms to provide unmatched genetic accuracy.

Join a world-class, multidisciplinary team to drive impactful R&D projects to improve our cutting-edge clinical offerings. Your work will advance a new generation of precision medicine products used by global biopharma and clinicians to transform cancer diagnostics and therapeutics.

Responsibilities:

• Organize and help perform internal proof of principle projects, development projects, and verification and validation exercises for liquid biopsy products in the Personalis portfolio.


• Work with the broader R&D organization to scope, track and troubleshoot liquid biopsy projects with internal and external collaborators and customers.


• Collaborate with process development, tech transfer, and operations teams to shepherd early stage products, product revisions, and early projects through to operations.


• Work with bioinformatics teams to plan experiments and analyze results.


• Identify problems in current processes and come up with troubleshooting approaches and


• Participate in meetings and present results.


• Use effective two-way communication to create and maintain a collaborative working environment.


• Support and ensure compliance with all department and company policies and procedures.

Education and Experience:

• Ph.D or MS with a minimum of 8 or 12 years of experience.


• Minimum of 2 years of laboratory experience in NGS and/or liquid biopsy focused molecular biology.


• Solid understanding of DNA/RNA manipulation.


• Excellent organization, documentation and communication skills.


• Passion for exploring new assays, hands-on experiment execution and creative thinking to solve problems.


• Excellent ability to multitask and troubleshoot complex protocols.


• Experience with automation (Hamilton or other liquid handlers) helpful.


• ISO13485 validation experience helpful.


• Data analysis skills with experience in Excel, JMP, R or Python.


• Prior experience working with a LIMS directed environment.


• Prior experience in cancer biology is strongly desired.

The hiring range for this position is $170,000 to $200,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

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