Staff Scientist, Platform Chemistry

THE ROLE

We are seeking a highly motivated and creative Chemist to support the Hit-Identification (Hit-ID) chemistry effort across our small molecule drug discovery programs.. Reporting to the Director,  Platform Chemistry, this individual will work collaboratively with Platform, Computational Chemistry, Data Science and Medicinal Chemistry teams to identify high quality small molecule leads. The successful candidate will also contribute to chemistry strategy and delivery of tool compounds to support continued development of the Native Complex Platform™. The Platform Team enables Hit-ID techniques for screening GPCR targets including DNA-Encoded Library (DEL) screening, small molecule cellular & biochemical High-Throughput Screening (HTS), and advanced approaches to solve ligand-bound GPCR structures for ultra-large library Virtual Screening (VS). An additional focus will be to improve methods and strategies for rapid compound synthesis (e.g. optimized workflows and vendors for off-DNA / HTS / VS hit synthesis) and parallelized hit-expansion (e.g. focused DEL or chemical library design and synthetic execution). 

QUALIFICATIONS

• Ph.D. in organic chemistry with at least 5+ years of experience in a biotechnology or pharmaceutical setting. The successful candidate will have expertise in the area of small molecule Hit-ID / early Leads, as applied to medicinal chemistry programs. 

REQUIREMENTS

• Experience and understanding of Hit-ID techniques including DNA-Encoded Library (DEL) screening, small molecule library cellular & biochemical High-Throughput Screening (HTS), and ultra-large library Virtual Screening (VS).


• Expertise in data analysis approaches for hit-picking, and prioritization of chemical hits including consideration of appropriate physical properties for future optimization and developability.


• Ability to execute on efficient follow-up chemistry with timely sourcing and/or synthesis of hit compounds and hit-expansion libraries.


• Demonstrated ability to collaborate cross-functionally.


• Outstanding communication skills.


• The successful candidate will be motivated to contribute to the discovery of new disease-modifying therapeutics for patients and enjoy working in a fast-paced dynamic team environment.

The anticipated salary range for candidates who will work in South San Francisco, CA is $150,000 - $165,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. 

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.