Vice President, Target Discovery, Validation, and Human Genetics

Define and execute an enterprise-level strategy for target discovery and validation, integrating human genetics and experimental biology to fuel Alnylam's RNAi pipeline. Lead and develop the Human Genetics and Discovery & Validation Biology teams, ensuring scientific excellence, clear prioritization, and sustained target delivery (>10 targets per year). Establish Alnylam as an industry leader in the application of large-scale human genetic data for drug target identification and prioritization. Oversee generation of rigorous, decision-enabling data packages to support target nomination and progression through governance forums. Partner cross-functionally with Research, Development, Commercial, and Finance to align discovery priorities with portfolio strategy and investment decisions. Identify, evaluate, and champion opportunities to expand Alnylam's access to genetic datasets, technologies, and external collaborations. Represent the discovery portfolio internally and externally, building credibility with senior leadership, partners, and the broader scientific community. PhD in human genetics, statistical genetics, molecular biology, or a related discipline, with deep scientific credibility in genetically driven drug discovery. 15+ years of progressive experience in biopharmaceutical research, including senior leadership roles with accountability for strategy, teams, and portfolio outcomes. Internationally recognized expert in human genetics-enabled target discovery, with a strong record of high-impact publications, target nominations, and/or pipeline contributions. Demonstrated ability to lead and integrate large, multidisciplinary teams spanning computational genetics, in vitro biology, and in vivo disease models. Proven track record of shaping discovery strategy and influencing portfolio-level investment decisions at the enterprise level. Strong business and matrix leadership skills, with experience partnering effectively across research, development, commercial, and corporate functions. Exceptional communication and executive presence, with the ability to articulate complex scientific concepts to diverse internal and external stakeholders.