VP, Financial Planning & Analysis

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.  

Role Summary:

The Vice President, FP&A will report to the Chief Financial Officer and serve as a strategic partner to Dyne’s Executive Committee.   You will lead all financial planning, forecasting, and resource allocation activities across R&D, G&A, and emerging Commercial functions. This role requires deep biotech/pharma expertise, particularly within a pre-launch or commercialized product, paired with a hands-on leadership style suitable for a scaling, dynamic environment.

This role is based in Waltham, MA without the possibility of being remote.

Key Responsibilities

Strategic Leadership

• Act as a financial thought partner to the EC, driving scenario-based decision-making on pipeline investments, commercial readiness, and capital allocation.


• Develop long-range financial models in partnership with Commercial Leadership, including revenue, COGS, and margin planning for first-in-class therapies.


• Partner cross-functionally with the CBO on strategic initiatives such as business development, pricing, lead valuation and NPV modeling.


• Represent Finance in investor, governance, and internal forums; translate complex science into clear, data-driven financial narratives.

Operational Excellence

• Lead the corporate planning cycle, including the annual budget, rolling forecasts, and long-range planning - ensuring alignment with strategy and SEC guidance.


• Manage budget vs. actual (BvA) reviews, variance analysis, and reporting with functional leads; deliver dashboards and KPIs that support decision-making.


• Standardize and enhance FP&A processes, leveraging tools enable scalable, data-informed operations.


• Build and lead a high-performing FP&A team capable of supporting both clinical and commercial growth.

 Education and Skills Requirements:

• Experience: 15+ years in FP&A, with at least 8 years in biotech/pharma; strong command of clinical development, commercial planning, and portfolio economics.


• Education: Bachelor’s degree in Finance, Accounting, Economics or a related field; MBA, CPA, or CFA preferred.


• Technical Skills: Advanced Excel and financial modeling; experience with ERP systems (NetSuite/Oracle), EPM tools (Adaptive/Anaplan), and BI platforms. Solid understanding of US GAAP and SOX compliance.


• Leadership: Proven ability to influence across functions, make decisions in ambiguity, and lead high-impact teams in a scaling environment.


• Commercial Focus: Experience developing launch P&Ls, demand forecasts, and product-level financial strategies for specialty or orphan drugs.


• Culture Fit: High integrity, mission-driven, and energized by building in a fast-paced biotech setting.

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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time.  The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.