RNA Scientist

Company : Yoh

Job Type : Full Time

Boston, Ma

Number of Applicants

:

000+

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Job Description - RNA Scientist

RNA Scientist (Protein Engineer)

Ginkgo Bioworks

Boston, MA- ON SITE

6 month W2 contract (Likely to extend or transition to perm)
Pay rate: $40-46/hour - Depending on Education and Experience

Summary:
A key enabling technology of our Mammalian RNA projects is the ability to produce circular RNA in high amounts. So far, this has been difficult for everyone in the RNA industry to achieve; Ginkgo is working to find solutions to this challenge. We currently have a process to enrich and purify circular RNA at scale and are working to improve it to produce a step-change in production output. This role will operate both existing and future RNA analytics and purification processes as they evolve.

Responsibilities:
Operate in-house processes for circular RNA (circRNA) and mRNA production, including running HPLC or FPLC, collecting and pooling chromatogram peaks, and reporting in LIMS.
Perform circRNA and mRNA purifications to support chromatography process development and the supply of 1 mg of material to support in-vivo mouse studies and aid in the development and supply of the 1 gram scale.
Analyze circRNA and mRNA fraction intermediates and final purified material analytically using agarose and PAGE gels, capillary gel electrophoresis (CGE), ELISAs, HPLC and other methods.
Use Ginkgo's Software and Automation infrastructure to execute production process and collaborate with software engineers to understand and provide feedback on how to improve upon Ginkgos LIMS and data capture pipeline
Work with other team members to drive standardization, quality processes and documentation towards improving our analytical infrastructure.
Develop processes for verification and quality control and participate in the implementation of quality controls to our assays to ensure low CV and high reproducibility

Skills or Requirements:
Lab experience in any of the following areas: chromatography, purification, enzymatics, analytics and/or general biotech laboratory work.
Basic knowledge of rudimentary analytical statistics (standard deviations, coefficients of variance, regression analysis, etc.)
Preferred Capabilities and Experience:
RNA biochemistry experience
Experience performing quantitative analyses using any of the techniques: CGE, Agarose Gel, PAGE, ELISA, qPCR/RT-PCR, HPLC / UPLC, SLS, DLS, Tm, SPR, BLI, CD
Direct experience analyzing data and reporting on analytical results
Prior experience working with automated and/or high throughput liquid handlers (Hamilton, LC autosamplers, automated workcells, etc
Demonstrated experience implementing quality controls in wet lab processes
Experience working within a cross functional environment
Knowledge of LEAN (or other organizational methodologies) to improve process efficiency and quality a plus.

Education/Experience:
AS or BS in biochemistry, biology, analytical chemistry, chemistry, chemical engineering, or equivalent degree + 2 years of related industry experience.

What's In It For You?
We welcome you to be a part of one of the largest global staffing companies to meet your career aspirations. Yoh's network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh's extensive talent community that will provide you with access to Yoh's vast network of opportunities and gain access to this exclusive opportunity available to you.
Medical, Dental & Vision Benefits
401K Retirement Saving Plan
Life & Disability Insurance
Direct Deposit & weekly ePayroll
Employee Discount Programs
Referral Bonus Programs
Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply. Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit to contact us if you are an individual with a disability and require accommodation in the application process.