Co-op: In-Vivo Delivery

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.  

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Fall 2026 Co-op Program: July – Dec 2026

Manager: Dorjee Shola Department: lung biology

_____________________________________________________________________________________

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in animal- and cellular-based studies to join the Lung Biology team. The candidate will be involved in supporting critical efforts in identifying delivery candidates for lung-directed dosing in animals towards the development of in vivo gene editing therapies that leverage our cutting-edge Prime Editing technologies. The successful candidate will thrive in a fast-paced research program and will enjoy working with colleagues within and across teams from multi-disciplinary backgrounds.

Primary Responsibilities:

· Assist and support lung delivery in-vivo studies, include dosing, takedown, tissue processing and antibody staining

· Plan and execute in vitro assays to evaluate gene editing activity in relevant cell models including primary lung bronchial epithelial cells

· Follow protocols, standard operating procedures, execute assigned tasks and maintain ELN. Share responsibility in lab reagent inventory and maintaining equipment.

· Work and collaborate cross-functionally with colleagues. Collect, analyze and present data in team meetings.

Required Qualifications:

· Bachelor/Master candidate in Biology related major

· Direct experience performing routine laboratory procedures and experiments

· Hands on experience with sterile techniques and culturing of mammalian cell culture including primary cells

· Comfortable working with rodent models with preliminary techniques or training on animal studies is a plus

Preferred Qualifications:

Experience with the following techniques or knowledge familiarities are preferred.

· Gene editing technologies (Cas9, base editing, prime editing etc)

· Non-viral delivery

· Animal dosing techniques (IV, IP, Oral, etc)

· Lung tissue processing, and cell staining for flow analysis

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.