Metcalf - XSD - Varanasi, Akanksha - 2.18.26

The Center for Structural Biology of Infectious Diseases carries a systematic structural characterization of essential enzymes from pathogens (bacteria and viruses) including, mycobacterial aaRSs and others, to facilitate structure-based drug design. High-resolution crystal structures of enzyme complexes with substrates, reaction intermediates, inhibitors and co-factors have been determined, revealing specific binding interactions. Collaborative efforts have enabled the identification and structural analysis of novel inhibitors targeting these enzymes, advancing the development of antimycobacterial therapeutics. Students will participate in molecular and structural biology experiments and data analysis.

Education and Experience Requirements

• The entirety of the appointment must be conducted within the United States.
• Must be 18 years or older at the time the appointment begins.
• Applicants must be:

• Currently enrolled in undergraduate or graduate studies at an accredited institution.
• Graduated from an accredited institution within the past 3 months; or
• Actively enrolled in a graduate program at an accredited institution.

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EEO Information

As an equal employment opportunity employer, and in accordance with our core values of impact, safety, respect, integrity and teamwork, Argonne National Laboratory is committed to a safe and welcoming workplace that fosters collaborative scientific discovery and innovation. Argonne encourages everyone to apply for employment. Argonne is committed to nondiscrimination and considers all qualified applicants for employment without regard to any characteristic protected by law.

Argonne employees, and certain guest researchers and contractors, are subject to particular restrictions related to participation in Foreign Government Sponsored or Affiliated Activities, as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation in the application phase for review by Argonne's Legal Department.