Summer intern Neuroscience

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling:  ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations.  

On August 8^th 2025, the U.S. Food and Drug Administration (FDA)  accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant.

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.

#TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com. 

Position Summary 

We are looking for a highly motivated individual to work as a summer intern from May to Aug 2026. The incumbent will be trained and mentored by Arvinas biology staff in the basic day-to-day processes that support preclinical drug discovery for neurology indications.  Through experiential learning, the selected candidate will become proficient in fundamental cellular and molecular biology techniques, the basic principles of pharmacology, data analysis, documentation, and interpretation.  Under the guidance of staff, the intern will implement basic scientific techniques at the bench, critically read, process, and present selected papers from the relevant scientific literature, and a summary of their work at an end-of-summer student colloquium.

This will be a full-time, wet-lab position, onsite position located at our headquarters in New Haven, CT (May-Aug 2026)

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Learn selected basic biology techniques from Arvinas staff with the goal of proficiency to the point of independently following detailed protocols to support in vitro pharmacology.

Techniques Including:   

• Cell culture, including CNS cell types.


• Evaluating cellular target engagement of putative ligands


• Quantitative protein analysis of PROTAC-mediated degradation and functional endpoints using in vitro CNS disease models (Western, luminescence-based readouts, and/or capillary immunoassay)

• Document experimental work in an Electronic Laboratory Notebook & learn associated ELN protocols


• Attend project meetings and internal seminars at the direction of Mentor


• Read and present key papers from the relevant scientific literature at Summer Student Journal Club

Qualifications

• Currently enrolled in an undergraduate degree program with a science discipline component


• Prior lab-based biology background, including coursework with a lab component, a plus but not required


• Prior independent research experience is a plus, but not required.


• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without the need for a current or future VISA sponsorship.  


• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

• Enrolled in college or graduate level course work to support B.S. or B.A. in relevant scientific discipline.

To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.