Principal Research Fellow (Monoclonal Antibody Discovery and Engineering)

Join Our Team at the School of Biological Sciences, Nanyang Technological University, Singapore

The School of Biological Sciences (SBS), part of the College of Science, was established in 2002 with a mission to advance biological and biomedical sciences. At SBS, our research spans various areas, including infectious diseases, immunology, neurodegenerative diseases, telomere biology, and genome function. Over the years, SBS has attracted talented individuals from around the world and Singapore to join as scientific leaders and researchers.

We are seeking a highly motivated Principal Research Fellow with strong expertise in antibody technologies and cancer biology to join our dynamic, multidisciplinary research team.

Key Responsibilities

• Perform phage display selection, screening, and optimization for monoclonal antibody discovery.

• Conduct mouse monoclonal antibody generation using hybridoma technology.

• Carry out antibody characterization (binding affinity, specificity, epitope mapping, stability).

• Engineer antibodies for enhanced function (Fc modifications, bispecific formats, humanization).

• Evaluate therapeutic efficacy in cell-based assays and murine tumor models.

• Develop the workflow for antibody generation and engineering.

• Collaborate with team members on research projects and contribute to manuscript preparation and grant applications.

Job Requirements

• PhD in Immunology, Molecular Biology, Biochemistry, Biomedical Sciences, or a related field.

• Proven experience in phage display or antibody discovery platforms.

• Hands-on expertise in protein expression, purification, and characterization (e.g., ELISA, SPR/BLI, FACS).

• Experience in hybridoma generation and in vivo mouse models of cancer is highly desirable.

• Strong analytical, organizational, communication and leadership skills.

• Ability to work both independently and collaboratively within a multidisciplinary team

The College of Science seeks a diverse and inclusive workforce and is committed to equality of opportunity. We welcome applications from all and recruit on the basis of merit, regardless of age, race, gender, religion, marital status and family responsibilities, or disability.

We regret that only shortlisted candidates will be notified.