Research Fellow (Cancer Science Institute)

Interested applicants are invited to apply directly at the NUS Career Portal. Please note your application will only be processed if you apply via NUS Career Portal.

NUS Career Portal link: https://careers.nus.edu.sg/job/Research-Fellow-%28Cancer-Science-Institute%29/33300-en_GB/

We regret that only shortlisted candidates will be notified.

Job Description

The Research Fellow will have opportunities to work with well-characterised clinical samples, state-of-the-art laboratory platforms, and an extensive network of local and international collaborators while contributing to high-impact publications and future clinical translation.

Key Responsibilities

• Design, plan, and execute independent research projects aligned with the laboratory's scientific objectives.
• Investigate mechanisms by which DNA damage and DNA repair defects influence innate and adaptive immune responses in cancer.
• Study immunogenic cell death, cytosolic nucleic acid sensing pathways, and tumour immune microenvironment modulation following genotoxic chemotherapy.
• Develop and optimise molecular and cellular assays related to DNA repair, immune activation, and cancer biology.
• Perform and interpret experiments using cell line models of epithelial and lymphoid malignancies.
• Apply quantitative microscopy and histopathological imaging techniques to investigate immune modulation pathways in human tumour samples.
• Analyse and interpret complex experimental datasets using appropriate statistical and computational approaches.
• Collaborate with clinicians and translational researchers to analyse patient-derived clinical specimens and develop clinically relevant biomarkers.
• Contribute to the design and evaluation of novel chemotherapy-immunotherapy combination strategies.
• Prepare manuscripts for publication in peer-reviewed journals and present findings at scientific conferences.
• Assist in preparing research grant applications and progress reports.
• Mentor graduate students, research assistants, and junior laboratory members where appropriate.
• Contribute to laboratory management, protocol development, and maintenance of high standards of scientific integrity and research compliance.
• Foster a collaborative, respectful, and inclusive research culture.

Qualifications

• PhD in Cancer Biology, Immunology, Molecular Biology, Cell Biology, Biomedical Sciences, Genetics, or a related discipline.
• Strong publication record in peer-reviewed scientific journals.
• Demonstrated expertise in one or more of the following:DNA damage response and DNA repair biologyCancer immunologyMolecular and cellular biologyImmunofluorescence and quantitative microscopyFlow cytometryCRISPR/Cas9 genome editingGenomic and transcriptomic analysesCancer cell culture and functional assays
• Experience working with animal models and/or human clinical specimens would be advantageous.
• Familiarity with bioinformatics or computational analysis of biological datasets is desirable.
• Excellent scientific writing, presentation, and communication skills.
• Ability to work both independently and collaboratively within multidisciplinary teams.